Transmembrane Glycoprotein
Transmembrane Glycoprotein
Transmembrane glycoproteins are important components of cell membranes and are characterized by oligosaccharide chains covalently linked to polypeptide chains. Glycosylation sites are mainly located in their extracellular regions, achieved by N-linked glycosylation (linked to asparagine residues) or O-linked glycosylation (linked to serine or threonine residues). Sugar chains not only provide structural stability to proteins but also confer functional specificity. Many transmembrane glycoproteins are receptors, such as G protein-coupled receptors (GPCRs) and receptor tyrosine kinases (RTKs). Most （clusters of differentiation）CD molecules are also transmembrane glycoproteins expressed on the surface of antigen-presenting cells[1][2].
References:
- [1]. L Franco, et al. The transmembrane glycoprotein CD38 is a catalytically active transporter responsible for generation and influx of the second messenger cyclic ADP-ribose across membranes. FASEB J. 1998 Nov;12(14):1507-20. [Content Brief]
- [2]. Kumi Oshima, et al. SHPS-1, a multifunctional transmembrane glycoprotein. FEBS Lett. 2002 May 22;519(1-3):1-7. [Content Brief]
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Transmembrane Glycoprotein Inhibitors
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Transmembrane Glycoprotein Agonists
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Transmembrane Glycoprotein Antagonists
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Transmembrane Glycoprotein Activators
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Transmembrane Glycoprotein Modulators
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Transmembrane Glycoprotein Ligands
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Transmembrane Glycoprotein Related Products (379)
Related Products (379)
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DS-1501
0 ImagesCat. No.: HY-P991365DS-1501 is a human monoclonal antibody (mAb) targeting Siglec-15/CD33L3. DS-1501 inhibits osteoclastogenesis. DS-1501 suppresses the decrease of lumbar spine bone mineral density (BMD) in ovariectomized (OVX) rats. DS-1501 can be used in Osteoporosis research. Recommended isotype control: Human IgG1 kappa, Isotype Control (HY-P99001).
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[Gln144]-PLP (139-151)
![[Gln144]-PLP (139-151)](https://file.medchemexpress.com/product_pic/hy-p10315.gif "Click to View [Gln144]-PLP (139-151) Product Detail")
0 ImagesCat. No.: HY-P10315CAS No.: 170033-42-8Synonyms: Q144-PLP(139-151)[Gln144]-PLP (139-151) is an experimental antigen used to study T cells respond to both autoantigens and cross-reactive non-autoantigens. [Gln144]-PLP (139-151) activates T cells by binding to T-cell Receptor (TCR), which triggers an immune response. [Gln144]-PLP (139-151) can be used to study the regulation of autoimmune diseases.
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TJU103
0 ImagesCat. No.: HY-W795993CAS No.: 10245-44-0TJU103 is a CD4 inhibitor. TJU103 inhibits autoreactive CD4+ T cells by disrupting the function of the CD4 during activation. TJU103 decreases mononuclear cell infiltration in brain and spinal cord tissue of experimental allergic encephalomyelitis (EAE) mice model. TJU103 downregulates Th1 and Th2 cytokine levels in response to proteolipid protein epitope 139-151 (PLPe) and exhibits inhibitory effects both after the appearance of EAE symptoms and upon rechallenge with Ag. TJU103 can be used for autoimmune diseases like EAE and sclerosis (MS) research.
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Anti-DSG3 Antibody
0 ImagesCat. No.: HY-P990403The Anti-DSG3 Antibody is a humanized antibody expressed in CHO cells, targeting DSG3. The Anti-DSG3 Antibody has a huIgG1 type heavy chain and a huκ type light chain, and its predicted molecular weight (MW) is 146.54 kDa. The isotype control for the Anti-DSG3 Antibody can be referenced as Human IgG1 kappa, Isotype Control (HY-P99001).
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Imaprelimab (powder)
0 ImagesCat. No.: HY-P99658A
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Anti-Mouse TIM-2 Antibody (RMT1-25)
0 ImagesCat. No.: HY-P991830Anti-Mouse TIM-2 Antibody (RMT1-25) reacts with the mouse TIM-2. TIM-2 is a type I cell surface glycoprotein. Recommend Isotype Controls: Rat IgG2a kappa, Isotype Control (HY-P990679).
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LinTT1 peptide
0 ImagesCat. No.: HY-P10786CAS No.: 2031154-77-3LinTT1 peptide is a tumor-penetrating peptide with the amino acid sequence AKRGARST. LinTT1 peptide targets peritoneal carcinoma (PC) by binding to the p32 (gC1qR) receptor. It can conjugate with iron oxide nanoworms (NWs) to form a nanocarrier. This nanocarrier is taken up by peritoneal carcinoma cells in vitro and enters the mitochondria; it also exhibits significant tumor targeting and penetration effects in mice. Moreover, LinTT1-functionalized nanocarriers, combined with the pro-apoptotic peptide [D(KLAKLAK)2], show significant tumor suppression in a mouse peritoneal tumor model. LinTT1 peptide holds promise as a delivery carrier for peritoneal cancer research.
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VCAM1 binding peptide
0 ImagesCat. No.: HY-P11088CAS No.: 1311293-04-5VCAM1 binding peptide is a VCAM1 binder with internalization activity. VCAM1 binding peptide can be labeled with 5-FAM. VCAM1 binding peptide serves as a component of biosensing systems for visualizing in vitro VCAM1 endocytic pathways. VCAM1 binding peptide forms the research and development basis for MacroP and NAMP, PET radiotracers targeting VCAM1. VCAM1 binding peptide is applicable to studies related to atherosclerosis.
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NOV1803
0 ImagesCat. No.: HY-P992425NOV1803 is a recombinant antibody targeting CD66.
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Telimomab
0 ImagesCat. No.: HY-P992089Telimomab is an anti-human monoclonal antibody targeting-CD5. Telimomab can be used for the research of immune disease.
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CBT004
0 ImagesCat. No.: HY-P992330Synonyms: KB312CBT004 (KB312) is a human IgG1κ type monoclonal antibody against CD83. CD83 is a type I transmembrane glycoprotein and is a highly expressed marker on the surface of mature DCs. It can also be induced to be expressed on activated B cells, some activated T cells, and activated monocytes.
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Anti-CD180 Antibody
0 ImagesCat. No.: HY-P992204
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DS-1055a (FUT8-KO)
0 ImagesCat. No.: HY-P992005ADS-1055a (FUT8-KO) is an anti-human GARP antibody that has knocked out the fucosyltransferase 8 gene (FUT8). It exhibits enhanced antibody-mediated cytotoxicity (ADCC) effect. DS-1055a (FUT8-KO) can effectively eliminate GARP-positive regulatory T cells in the tumor microenvironment and activate effector T cells. DS-1055a (FUT8-KO) has anti-tumor activity and can be used in cancer research (such as colon cancer).
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CNTO-860
0 ImagesCat. No.: HY-P991619CAS No.: 808771-06-4Synonyms: TF8-5G9CNTO-860 is a humanized anti-tissue factor monoclonal antibody. CNTO-860 can improve tumor control when combined with Paclitaxel (HY-B0015) in colon cancer model and significantly increase tumor-free survival.
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(E/Z)-Sulfosuccinimidyl oleate sodium
0 ImagesCat. No.: HY-112847BCAS No.: 1212012-37-7Synonyms: (E/Z)-Sulfo-N-succinimidyl oleate sodium(E/Z)-Sulfosuccinimidyl oleate sodium is the racemate of (E)-Sulfosuccinimidyl oleate sodium and (Z)-Sulfosuccinimidyl oleate sodium. Sulfosuccinimidyl oleate sodium (Sulfo-N-succinimidyl oleate sodium) is a long-chain fatty acid that inhibits fatty acid transport into cells. Sulfosuccinimidyl oleate sodium is a potent and irreversible inhibitor of the mitochondrial respiratory chain. Sulfosuccinimidyl oleate sodium binds to the CD36 receptor on the surface of microglial cells. Sulfosuccinimidyl oleate sodium exhibits anti-inflammatory effects.
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Anti-BST1 Antibody
0 ImagesCat. No.: HY-P991884
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Anti-Mouse CD80/B7-1 Antibody (1G10)
0 ImagesCat. No.: HY-P991831Anti-Mouse CD80/B7-1 Antibody (1G10) reacts with mouse CD80 that can block CD80 in vivo. Recommend Isotype Controls: Rat IgG2a kappa, Isotype Control (HY-P990679).
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Epinastine-13C,d3 hydrobromide
0 ImagesCat. No.: HY-B0640SSynonyms: WAL801-13C,d3 hydrobromideEpinastine-13C,d3 (hydrobromide) is the 13C- and deuterium labeled Epinastine. Epinastine (WAL801) is an antihistamine and mast cell stabilizer. Epinastine is a potent, selective and orally-active histamine H1 receptor antagonist. Epinastine also inhibits IL-8 release and has an antiallergic action.
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Anti-Siglec-10/CD24 Antibody
0 ImagesCat. No.: HY-P992303
